Protein Details: Acid-sensing ion channel 1A

Protein ID

ICDB_Pro_1133

Protein Name

Acid-sensing ion channel 1A

Gene Name

asic1a; accn2b

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

501 amino acids

AlphaFoldDB

AF-Q708S7-F1-model_v4.pdb

Function

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions; but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

Sequence

MKTSVMDLKVEPMDIDFDQPPPLQVFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLDEITTPVMVFPAVTICNLNSIRFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPEDFSVVFTRYGKCYTFNSGETGPPRVSVKGGMGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYSISACRTDCETRYLVENCNCRMVHMPGDAPYCTPVLYKECAHPALDFLVETDSDYCSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYEVMKYRLCRCSNKKHHNNNNNTDHNAVFSLDDVNCHVSKFH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 76: "Important for channel gating"; SITE 84: "Important for channel desensitizing"; SITE 291: "Important for channel gating"

Disease

Location

Expressed in central nervous system. Faintly expressed in the trunk; presumably in dorsal root ganglia.

DOI ID

10.1074/jbc.m401477200

RefSeq

NP_999955.1; XP_009302015.1